Publications
2026
58. Examining Human Relevance in Recapitulating Lower Extremity Flow and Valve Function in New Approach Methods (NAMs)
S. Suresh, R. Dhar, C. E. Evans, M. Hoofnagle, A. Jain
Small (2026)
2025
57. Evidence for Drop-Like Nuclear Deformation in Sheared Endothelial Monolayers
Mohammad Mohajeri, Ting-Ching Wang, Pooja Agarwal, Simran Kaur, Ankit Kumar, Richard B. Dickinson, Abhishek Jain, Tanmay P. Lele
Small (2025)
56. Towards Targeting of Inflammasome Signaling in Venous Thrombosis
Rana Dhar, Rinaldo R. Dos Passos, R.Michael Gower, Abhishek Jain, Colin Evans
Journal of Thrombosis and Haemostasis (2025)
54. Transforming Growth Factors in Venous Thrombus Formation and Resolution
Davis, J., Maranto, M., Kennedy, J., Wang, X., Azhar, M., Jain, A., Evans, C.E.
Arteriosclerosis, Thrombosis, and Vascular Biology (2025)
53. Vascular architecture-on-chip: engineering complex blood vessels for reproducing physiological and heterogeneous hemodynamics and endothelial function
Lee, J.D., Kumar, A., Mathur, T., Jain, A.
Lab on a Chip (2025)
52. Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease
Casso-chapa, B., Norma A.V.G., Le, Nhat-Tu,…, Jain, A.,…, Abe, Jun-ichi
Arteriosclerosis, Thrombosis, and Vascular Biology (2025)
2024
51. Engineering and Evaluating Vascularized Organotypic Spheroids On-Chip
Tronolone, J.J., Mohamed, N., Chaftari, C.P., Sun, Y., Mathur, T., Jain, A.
Current Protocols (2024)
50. Granular Biphasic Colloidal Hydrogels for 3D Bioprinting
Deo, K. A., Murali, A., Tronolone, J. J., Mandrona, C., Lee, H. P., Rajput, S., Hargett, S. E., Selahi, A., Sun, Y., Alge, D. L., Jain, A., & Gaharwar, A. K.
Advanced Healthcare Materials (2024)
49. Mitigating Vascular Inflammation by Mimicking AIBP Mechanisms: A New Therapeutic End for Atherosclerotic Cardiovascular Disease
Kim, J.D., Jain, A., Fang, L.
International Journal of Molecular Sci. (2024)
48. A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
Banerjee, P., Chau, K., Kotla, S., Davis, E.L., Turcios, E.B., Pengzhi, S.L.Z., Wang, G., Kolluru, G.K., Jain, A., Cooke, J.P., Abe, J., Le, N.T.
Current Atherosclerosis Reports (2024)
47. GHSR Deletion in β-Cells of Male Mice: Ineffective in Obesity, but Effective in Protecting against Streptozotocin-Induced β-Cell Injury in Aging
Han, H.W., Pradhan, G., Villarreal, D., Kim, D.M., Jain, A., Gaharwar, A., Tian, Y., Guo, S., Sun, Y.
Nutrients (2024)
46. AngioMT: A MATLAB based 2D image-to-physics tool to predict oxygen transport in vascularized microphysiological systems
Mathur, T., Tronolone, J. J., & Jain, A.
PLoS ONE (2024)
45. Angiogenesis-Enabled Human Ovarian Tumor Microenvironment-Chip Evaluates Pathophysiology of Platelets in Microcirculation
Ghosh, L.D., Mathur, T., Tronolone, J.J., Chuong, A., Rangel, K., Corvigno, S., Sood, K.A., Jain, A.
Advanced Healthcare Materials (2024)
44. Engineering Lymphangiogenesis-On-Chip: The Independent and Cooperative Regulation by Biochemical Factors, Gradients, and Interstitial Fluid Flow
Tronolone, J. J., Mohamed, N. & Jain, A.
Advanced Biology (2024)
2023
43. The prospects of microphysiological systems in modeling platelet pathophysiology in cancer
Ghosh, L.D. & Jain, A.
Platelets (2023)
42. Machine learning chained neural network analysis of oxygen transport amplifies the physiological relevance of vascularized microphysiological systems
Tronolone, J. J., Mathur, T., Chaftari, C. P., Sun, Y. & Jain, A.
Bioengineering & Translational Medicine (2023)
41. Electrically stimulated gene expression under exogenously applied electric fields
Abasi, S., Jain, A., Cooke, J. P., Guiseppi-Elie, A.
Frontiers in Molecular Biosciences (2023)
40. Evaluation of the Morphological and Biological Functions of Vascularized Microphysiological Systems with Supervised Machine Learning
Tronolone, J. J., Mathur, T., Chaftari, C. P., & Jain, A.
Annals of Biomedical Engineering (2023)
2022
39. Engineered models of the lymphatic vascular system: Past, Present, and Future
Selahi, A. & Jain, A.
Microcirculation (2022)
38. Vascular Transcriptomics: A Protocol for Investigating Endothelial Activation and Vascular Dysfunction Through Blood Outgrowth Endothelial Cells, Organ-Chips and RNA Sequencing
Mathur, T., Kumar, A, Flanagan, J. M., & Jain, A.
Current Protocols (2022)
37. Intracellular calcium dynamics of lymphatic endothelial and muscle cells co-cultured in a Lymphangion-Chip under pulsatile flow
Selahi, A., Chakraborty, S., Muthuchamy, M., Zawieja, D. C., Jain, A.
Analyst (2022)
36. Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications
Banerjee, P., Olmsted-Davis, E. A., Deswal, A., Nguyen, M.Th., Koutroumpakis, E., Palaskas, N.L., Lin, S.H., Kolta, S., Reyes-Gibby, C., Yeung, SC.J., Yusuf, S.W., Yoshimoto-Kobayashi, M., Kobayashi, M., Yu, B., Schadler, K., Herrmann, J., Cooke, J.P., Jain, A., Chini, E., Le, N.T., Abe, J.I.
The Journal of Cardiovascular Aging (2022)
35. In silico analyses of blood flow and oxygen transport in human micro-veins and valves
Pandian, N. K. R., & Jain, A.
Clinical Hemorheology & Microcirculation (2022)
34. 2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath
S. Rajput, K.A. Deo, T. Mathur, G. Lokhande, K.A. Singh, Y. Sun, D.L. Alge, A. Jain, T.R. Sarkar, A.K. Gaharwar
Bioprinting (2022)
33. Lymphangion-chip: a microphysiological system which supports co-culture and bidirectional signaling of lymphatic endothelial and muscle cells
Selahi, A., Fernando, T., Chakraborty, S., Muthuchamy, M., Zawieja, D. C., Jain, A.
Lab on a Chip (2022)
2016 – 2021
32. Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy
Cooke, J.P., Connor, J.H., Jain, A.
Methodist DeBakey Cardiovascular Journal (2021)
31. Comparative Analysis of Blood‐Derived Endothelial Cells for Designing Next‐Generation Personalized Organ‐on‐Chips
Mathur, T., Tronolone, J. J., & Jain, A.
Journal of the American Heart Association (2021)
30. Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting
Xin, S., Deo, K. A., Dai, J., Pandian, N. K. R., Chimene, D., Moebius, R. M., Jain, A., Han, A., Gaharwar, A. K., Alge, D. L.
Science Advances (2021)
29. Self-Oscillating 3D Printed Hydrogel Shapes
Nava-Medina, I. B., Gold, K. A., Cooper, S. M., Robinson, K., Jain, A., Cheng, Z. D., Gaharwar, A. K.
Advanced Material Technologies (2021)
28. 3D Bioprinted Multicellular Vascular Models
Gold, K. A., Saha, B., Pandian, N. K. R., Walther, B. K., Palma, J. A., Jo, J., Cooke, J. P., Jain, A.*, & Gaharwar, A. K.*
Advanced Healthcare Materials (2021)
27. Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer.
Saha, B., Mathur, T., Tronolone, J. J., Chokshi, M., Lokhande, G. K., Selahi, A., Gaharwar, A. K., Afshar-Khargan, V., Sood, A. K., Bao, G., & Jain, A.
Science Advances (2021)
26. Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response
Walther, B. K., Pandian, N. K. R., Gold, K., Kiliç, E. S., Sama, V., Gu, J., Gaharwar, A. K., Guiseppi-Elie, A., Cooke, J. P., & Jain, A.
Lab on a Chip (2021)
25. Engineering New Microvascular Networks On-Chip: Ingredients, Assembly, and Best Practices
Tronolone, J. J., & Jain, A.
Advanced Functional Materials (2021)
24. Tripartite collaboration of blood-derived endothelial cells, next generation RNA sequencing and bioengineered vessel-chip may distinguish vasculopathy and thrombosis amongst sickle cell disease patients.
Mathur, T., Flanagan, J. M., & Jain, A.
Bioengineering & Translational Medicine (2021)
23. Microengineered Human Vein‐Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis
Pandian, N. K. R., Walther, B. K., Suresh, R., Cooke, J. P., & Jain, A.
Small (2020)
22. Thromboresistance of Polyurethanes Modified with PEO-Silane Amphiphiles
Ngo, B. K. D., Lim, K. K., Johnson, J. C., Jain, A., & Grunlan, M.
Macromolecular Bioscience (2020)
21. OvCa-Chip microsystem recreates vascular endothelium–mediated platelet extravasation in ovarian cancer
Saha, B., Mathur, T., Handley, K. F., Hu, W., Afshar-Kharghan, V., Sood, A. K., & Jain, A.
Blood Advances (2020)
20. Thromboresistance of Silicones Modified with PEO-Silane Amphiphiles
Ngo, B. K. D., Barry, M. E., Lim, K. K., Johnson, J. C., Luna, D. J., Pandian, N. K. R., Jain, A., & Grunlan, M.
ACS Biomaterials Science & Engineering (2020)
19. Tortuosity-powered microfluidic device for assessment of thrombosis and antithrombotic therapy in whole blood
Luna, D. J., Pandian, N. K. R., Mathur, T., Gadangi, P., Kostousov, V. V., Hui, S.-K. R., Teruya, J., & Jain, A.
Nature Scientific Reports (2020)
18. Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips
Mathur, T., Singh, K. A., Pandian N.K.R., Tsai, S. H., Hein, T. W., Gaharwar, A. K., Flanagan, J. M., & Jain, A.
Lab on a Chip (2019)
17. Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing
Gold, K., Gaharwar, A. K., & Jain, A.
Biomaterials (2019)
16. Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models
Papa, A. L., Jiang, A., Korin, N., Chen, M. B., Langan, E. T., Waterhouse, A., Nash, E., Caroff, J., Graveline, A., Vernet, A., Mammoto, A., Mammoto, T., Jain, A., Kamm, R. D., Gounis, M. J., & Ingber, D. E.
Science Translational Medicine (2019)
15. Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems
Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano,D., Nguyen J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A., Otieno, M. A.
Clinical Pharmacology & Therapeutics (2018)
14. PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury
De Ceunynck K., Peters C. G., Jain A., Higgins S. J., Aisiku O., Fitch-Tewfik J. L., Dockendorff C., Parikh S. M., Ingber D. E., & Flaumenhaft R.
PNAS (2018)
13. Thrombosis-on-a-chip: Prospective impact of microphysiological models of vascular thrombosis
Pandian, N. K. R., Mannino, R. G., Lam, W. A., & Jain, A.
Current Opinion in Biomedical Engineering (2018)
12. Engineering “Endothelialized” Microfluidics for Investigating Vascular and Hematologic Processes Using Non-Traditional Fabrication Techniques
Mannino, R. G., Pandian, N. K. R., Jain, A., Lam, W. A.
Current Opinion in Biomedical Engineering (2018)
11. A primary human lung alveolus‐on‐a‐chip model of intravascular thrombosis for assessment of therapeutics
Jain, A.*, Barrile, R.*, van der Meer, A. D., Deceunynck, K., Mammoto, A., Mammoto, T., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R., & Ingber, D. E.
Clinical Pharmacology & Therpaeutics (2018)
10. Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium
Jain, A.*, van der Meer, A. D.*, Papa, A. L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L., & Ingber, D. E.
Biomedical Microdevices (2016)
9. A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function
Jain, A., Graveline, A., Waterhouse, A., Vernet, A., Flaumenhaft, R., & Ingber, D. E.
Nature Communications (2016)
2005-2015
View Publications
8. Engineered in vitro disease models
Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang KJ, Karalis K, Kim HJ, MacQueen L, Mahmoodian R, Musah S, Torisawa YS, van der Meer AD, Villenave R, Yadid M, Parker KK, Ingber DE.
Annual Review of Pathology (2015)
7. A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling
Leslie DC, Waterhouse A, Berthet JB, Valentin TM, Watters AL, Jain A, Kim P, Hatton BD, Nedder A, Donovan K, Super EH, Howell C, Johnson CP, Vu TL, Bolgen DE, Rifai S, Hansen AR, Aizenberg M, Super M, Aizenberg J, Ingber DE.
Nature Biotechnology (2014)
6. A microdevice for rapid optical detection of magnetically captured rare blood pathogens
Cooper RM, Leslie DC, Domansky K, Jain A, Yung C, Cho M, Workman S, Super M, Ingber DE.
Lab Chip (2014)
5. Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip
Jain A, Munn LL.
Lab Chip (2011)
4. Determinants of leukocyte margination in rectangular microchannels
Jain A, Munn LL.
PLoS One (2009)
3. Particle dispersion and separation resolution of pinched flow fractionation
Jain A, Posner JD.
Analytical Chemistry (2008)
2. Flow characteristics in a model can combustor: Effect of casting angle
Jain, A., Choudhary, S., Singh, S. N., Rai, L.
Journal of the Institution of Engineers (India): Mechanical Engineering Division (2006)
1. Flow analysis in a model can-type gas turbine combustor
Jain, A., Choudhary, S., Rai, L., Singh, S. N.
Indian Journal of Engineering & Materials Sciences (2005)
Book Chapters
1. Organ-on-a-chip and 3D printing as preclinical models for medical research and practice
Jain, A., Mathur, T., Pandian, N. K. R., & Selahi, A.
Precision Medicine for Investigators, Practitioners and Providers (pp. 83-95), Academic Press (2020)
2. Lab on a chip technologies and applications
Munn, L. L., & Jain, A.
Design and fabrication of microfluidic devices for flow-based separation of blood cells, UK: Horizon Scientific Press (2008)
Abhishek Jain: The Bioinspired Translational Microfluidics Lab 