BioinSyst

we engineer next generation organ-chips

Animals have long been the bedrock behind our understanding of human physiology and drug discovery despite the awareness of the discordance between animal and human studies. In past three decades, the number of FDA-approved drugs per billion US dollars spent on R&D has actually decreased monotonically. Our research aspires to reverse this poor trend by innovating new bioengineered approaches, paradigms and tools that make a positive impact to medicine and healthcare economics.

Our lab is achieving this ambition by harnessing basic knowledge and methods offered by cell and molecular biology, biomechanics, microfabrication technology, biomaterials, and mathematics; and reconstructing the physical microenvironment of human tissues and organs in microfluidic devices, also known as organs-on-chip. We envision the organ-chip as a platform with tremendous potential to enable scientific discoveries of the future. Our lab specializes in making patient-specific organ-chip models of rare and orphan diseases with an emphasis on blood and lymphatic systems and their long-term manifestations in cancer, diabetes, and infections.